Dimerin

Dimerin Uses, Dosage, Side Effects, Food Interaction and all others data.

Dimerin is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now limited. Dimerin was withdrawn from the U.S. market in June 1965 and the Canadian market in September 1990 due to adverse events.

Dimerin, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a "non-barbiturate" sedative-hynotic. Dimerin is used for insomnia and daytime tension. Dimerin depresses the activity of muscle tissues, the heart, and the respiratory system.

Trade Name Dimerin
Generic Methyprylon
Methyprylon Other Names Methyprylon, Methyprylone, Methyprylonum, Metiprilon, Metiprilona, Metiprilone
Type
Formula C10H17NO2
Weight Average: 183.2475
Monoisotopic: 183.125928793
Protein binding

60%

Groups Approved, Illicit, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dimerin
Dimerin

Uses

For the treatment of insomnia.

How Dimerin works

Dimerin binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of overdose include excitation and convulsions.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Half Life

6-16 hours

Innovators Monograph

You find simplified version here Dimerin

*** Taking medicines without doctor's advice can cause long-term problems.
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