Dimetacrine Uses, Dosage, Side Effects and more
Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. Dimetacrine is no longer used in Japan.
Little is known about the pharmacology of dimetacrine.
| Attribute | Details |
|---|---|
| Trade Name | Dimetacrine |
| Generic | Dimetacrine |
| Dimetacrine Other Names | Dimetacrine, Istonil, Istonyl, Linostil, Miroistonil |
| Type | |
| Formula | C20H26N2 |
| Weight | Average: 294.4338 Monoisotopic: 294.209598842 |
| Groups | Experimental, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Toxicity
Dimetacrine may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants.
Volume of Distribution
The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397).
Half Life
Approximately 10 hours. (PMID 5312397)
Elimination Route
Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397)
