Istonyl

Istonyl Uses, Dosage, Side Effects, Food Interaction and all others data.

Istonyl is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Istonyl is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. Istonyl is no longer used in Japan.

Little is known about the pharmacology of dimetacrine.

Trade Name Istonyl
Generic Dimetacrine
Dimetacrine Other Names Dimetacrine, Istonil, Istonyl, Linostil, Miroistonil
Type
Formula C20H26N2
Weight Average: 294.4338
Monoisotopic: 294.209598842
Groups Experimental, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Istonyl
Istonyl

Toxicity

Istonyl may induce severe cardiac toxicity in overdose. This property is unique among the tricyclic antidepressants.

Volume of Distribution

The highest concentrations of dimetacrine were found at 1 hour after administration but at 3 hours in brain, heart, lung, liver, spleen, kidney, skeletal muscle and adipose tissue of testes. (Carried out in mice, PMID 5312397).

Half Life

Approximately 10 hours. (PMID 5312397)

Elimination Route

Approximately 70% of the doses were excreted in urine and feces within 2 days after treatment. (PMID 5312397)

Innovators Monograph

You find simplified version here Istonyl

*** Taking medicines without doctor's advice can cause long-term problems.
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