Dimethoxybenzylidene Anabaseine
Dimethoxybenzylidene Anabaseine Uses, Dosage, Side Effects, Food Interaction and all others data.
Dimethoxybenzylidene Anabaseine (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. Dimethoxybenzylidene Anabaseine has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study in healthy adults, Dimethoxybenzylidene Anabaseine also demonstrated cognitive enhancement across all doses, with a statistically significant improvement in attention related and memory related tasks (Kitagawa, et al. Neuropsychopharmacology (2003), 28, 542-551).
| Trade Name | Dimethoxybenzylidene Anabaseine |
| Generic | GTS-21 |
| GTS-21 Other Names | Dimethoxybenzylidene anabaseine, DMXB-A, DMXB-Anabaseine |
| Type | |
| Formula | C19H20N2O2 |
| Weight | Average: 308.3743 Monoisotopic: 308.152477894 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders.
How Dimethoxybenzylidene Anabaseine works
Auditory sensory gating, a biological measurement of the ability to suppress the evoked response to the second of two auditory stimuli, is diminished in people with schizophrenia. Deficits in sensory gating are associated with attentional impairment, and may contribute to cognitive symptoms and perceptual disturbances. This inhibitory process, which involves the alpha(7) nicotinic receptor mediated release of gamma-aminobutyric acid (GABA) by hippocampal interneurons, represents a potential new target for therapeutic intervention in schizophrenia. Dimethoxybenzylidene Anabaseine is an orally active alpha-7 nicotinic acetylcholine (nACh) receptor agonist.
Elimination Route
Rapidly and extensively absorbed after oral administration. In rat, Dimethoxybenzylidene Anabaseine showed linear pharmacokinetics over doses ranging from 1 to 10 mg/kg with an absolute bioavailability of 23%. In dog, the absolute bioavailability was 27% at an oral dose of 3 mg/kg.
Innovators Monograph
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