Dipotassium Hydrogen Phosphate

Dipotassium Hydrogen Phosphate Uses, Dosage, Side Effects, Food Interaction and all others data.

Dipotassium Hydrogen Phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Trade Name Dipotassium Hydrogen Phosphate
Generic Dipotassium phosphate
Dipotassium phosphate Other Names Di-potassium hydrogen phosphate, Dibasic potassium phosphate, Dipotassium acid phosphate, Dipotassium hydrogen monophosphate, Dipotassium hydrogen orthophosphate, Dipotassium hydrogen phosphate, Dipotassium monophosphate, Kali phosphoricum, Potassium phosphate dibasic, Secondary potassium phosphate
Type
Formula HK2O4P
Weight Average: 174.1759
Monoisotopic: 173.888658754
Protein binding

Phosphate is minimally protein bound, and highly concentrated in cells (intracellular concentrations are 100-fold higher than serum concentrations). Concentrations of phosphate in plasma are higher in children than in adults.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dipotassium Hydrogen Phosphate
Dipotassium Hydrogen Phosphate

Uses

Dipotassium Hydrogen Phosphate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.

Dipotassium Hydrogen Phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium Hydrogen Phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.

Dipotassium Hydrogen Phosphate is also used to associated treatment for these conditions: Electrolyte imbalance, Mild Metabolic acidosis, Fluid replacement therapy, Parenteral rehydration therapy, Total parenteral nutrition therapy, Urine alkalinization therapy, Fluid and electrolyte maintenance

How Dipotassium Hydrogen Phosphate works

Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives.

Toxicity

LD50 not available. Toxic effects in humans: Irritated skin, eye. Gastro intestinal irritation with nausea, vomiting, diarrhea, abdominal discomfort

Food Interaction

No interactions found.

Volume of Distribution

Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.

Elimination Route

Potassium salts are well absorbed from gastro intestinal tract. Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses.

Half Life

In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.

Clearance

Phosphates are rapidly cleared by dialysis.

Elimination Route

Potassium is excreted primarily by kidney.

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