Disodium Hydrogen Monophosphate

Disodium Hydrogen Monophosphate Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium phosphate inceases fecal water content to increase mobility through the large intestine .

Trade Name Disodium Hydrogen Monophosphate
Generic Sodium phosphate, dibasic
Sodium phosphate, dibasic Other Names Disodium acid phosphate, Disodium hydrogen monophosphate, Disodium hydrogen phosphate, disodium hydrogenphosphate, Disodium phosphate, Sodium phosphate dibasic, Sodium phosphate, dibasic
Type
Formula HNa2O4P
Weight Average: 141.9588
Monoisotopic: 141.940784382
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Disodium Hydrogen Monophosphate
Disodium Hydrogen Monophosphate

Uses

Disodium Hydrogen Monophosphate is an osmotic laxative used to cleanse the colon before a colonoscopy.

Used to treat constipation or to clean the bowel before a colonoscopy .

Disodium Hydrogen Monophosphate is also used to associated treatment for these conditions: Constipation, Hypophosphatemia, Severe constipation, Total parenteral nutrition therapy

How Disodium Hydrogen Monophosphate works

Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen .

Toxicity

Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats . Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma . Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients .

Food Interaction

  • Take with a full glass of water.
  • Take with food.

Elimination Route

Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h .

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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