Dxproxil Powder for Suspension 40 mg/5 ml
Dxproxil Powder for Suspension 40 mg/5 ml Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Dxproxil Powder for Suspension 40 mg/5 ml |
| Generic | Cefpodoxime Proxetil |
| Weight | 40 mg/5 ml |
| Type | Powder for Suspension |
| Therapeutic Class | Third generation Cephalosporins |
| Manufacturer | Monicopharma Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Cefpodoxime is indicated for the treatment of infections caused by susceptible microorganism, listed below: Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis (including beta-lactamase producing strains). Pharyngitis/tonsillitis caused by Streptococcus pyogenes. ... Read moreDosage
Dxproxil Powder for Suspension 40 mg/5 ml dosage
Adults and Adolescents (13 years and older)- Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days Acute maxillary sinusitis: 200 mg 12 hourly, 10 day Community-acquired pneumonia: 200 mg 12 hourly, 14 days Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days Skin and skin structure: 400 mg 12 hourly, 7 to 14 days Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days Uncomplicated gonorrhea: single dose of 200 mg Rectal gonococcal infections in women: single dose of 200 mg Infants and Pediatric Patients (2 months to 12 years)- Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance <30ml/min) the dosing intervals should be increased to 24 hourly.Patients with liver cirrhosis: Dxproxil Powder for Suspension 40 mg/5 ml pharmacokinetics in cirrhotic patients are similar to those in healthy subjects. Dose adjustment is not necessary in this population.Side Effects
Cefpodoxime has very few side effects. The side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children incidence of fungal skin rash is more than adults.Precaution
In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of Dxproxil Powder for Suspension 40 mg/5 ml should be reduced. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other broad spectrum antibiotics, prolonged use of Dxproxil Powder for Suspension 40 mg/5 ml may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient’s condition is essential.Interaction
Antacids: Concomitant administration of high doses of antacids (sodium bicarbonate and aluminium hydroxide) or H 2 blockers reduce peak plasma level by 24% to 42% and the extent of absorption by 27% to 32%, respectively.Probenecid: Renal excretion of cefpodoxime was inhibited by probenecid and resulted in an approximately 31% increase in AUC.Nephrotoxic drugs: Close monitoring of renal function is advised when Dxproxil Powder for Suspension 40 mg/5 ml is administered concomitantly with compounds of known nephrotoxic potential.Pregnancy & Breastfeeding use
Cefpodoxime was neither teratogenic nor embryocidal in animal trial. There is, however, no adequate and well-controlled study of Dxproxil Powder for Suspension 40 mg/5 ml use in pregnant woman. The drug should be used during pregnancy only if clearly needed. Because Cefpodoxime is excreted in human milk, a decision should be made wheather to discontinue breast-feeding or to discontinue the drug.Contraindication
Dxproxil Powder for Suspension 40 mg/5 ml is contraindicated in patients with a known allergy to Cefpodoxime or to the cephalosporin group of antibiotics.Storage Condition
Keep in a dry place away from light and heat. Keep out of the reach of children.Innovators Monograph
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