Klor-con/ef
Klor-con/ef Uses, Dosage, Side Effects, Food Interaction and all others data.
Klor-con/ef is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. It is used in medicine as an antacid. It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids. This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.
Potassium is the principal intracellular cation in most body tissues. The concentration of potassium ions is essential to conduct nerve impulses in specialized tissues like brain, heart and skeletal muscle, as well as to maintain normal renal function, acid-base balance, and cellular metabolic functions. The use of compounds containing bicarbonate is showed to produce the release of CO2. This effect has been one of the problems of the use of potassium bicarbonate as it can cause eructation.
| Trade Name | Klor-con/ef |
| Generic | Potassium bicarbonate |
| Potassium bicarbonate Other Names | Potassium bicarbonate, Potassium hydrogen carbonate |
| Weight | 10meq, 20meq, 25meq |
| Type | Oral tablet, effervescent |
| Formula | CHKO3 |
| Weight | Average: 100.1151 Monoisotopic: 99.956275759 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Klor-con/ef is an ingredient used as an antacid or to treat hypokalemia.
Klor-con/ef is used as an antacid, electrolyte replenisher and potassium supplement. It can also be used as an excipient in drug formulations. An antacid is a medication used to neutralize gastric acid in a short timeframe after ingestion and the effect is soon overcome by meal-stimulated acid secretion.
Klor-con/ef is also used to associated treatment for these conditions: Arrhythmias Cardiac caused by Hypokalemia, Gastro-esophageal Reflux Disease (GERD), Hypocitraturia, Hypokalemia, Ketoacidosis caused by Hypokalemia, Kidney Stones, Neuromuscular Disorders caused by Hypokalemia, Uric Acid Stones, Calcium oxalate calculi Renal Calculi
How Klor-con/ef works
The antacid potential of potassium bicarbonate is attained by increasing the gastrointestinal pH by neutralizing hydrochloric acid. The increase in pH results in suppression of the action of pepsin which is the enzyme that exacerbates ulceration due to the presence of acid.
Toxicity
Klor-con/ef does not contain any toxic chemicals and it is not listed as a carcinogenic or a potential carcinogen. Klor-con/ef is also considered safe in pregnancy as the current data do not suggest a teratogenic potential or any developmental toxicity.
Food Interaction
- Avoid potassium-containing products. Excess potassium intake may cause hyperkalemia. Avoid salt substitutes like potassium chloride (KCl).
- Take with a full glass of water. Dissolve the 10 mEq tablet in at least 2-3 oz of fluid, and the 20 mEq tablet in at least 3-4 oz of liquid (juice or water).
- Take with food.
Elimination Route
Klor-con/ef intake is done mainly in the small intestine in which approximately 90% of the potassium will be absorbed by passive diffusion.
Half Life
Some reports have shown that after absorption, most body potassium exchanges rapidly with a half-life of less than 7 hours.
Elimination Route
Approximately 90% of the exogenous potassium consumed is lost in the urine while the other 10% is excreted in feces and a very small amount can be found in the sweat. The excreted potassium is freely filtered by the glomerulus of the kidney.
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