Eldesine
Eldesine Uses, Dosage, Side Effects, Food Interaction and all others data.
Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Eldesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).
Eldesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer. Eldesine causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Eldesine and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Eldesine has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.
Trade Name | Eldesine |
Generic | Vindesine |
Vindesine Other Names | Desacetylvinblastine amide, Vindesina, Vindesine, Vindesinum |
Type | |
Formula | C43H55N5O7 |
Weight | Average: 753.941 Monoisotopic: 753.410149131 |
Protein binding | 65-75% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Eldesine is a vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).
For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
Eldesine is also used to associated treatment for these conditions: Acute Lymphocytic Leukemia (ALL), Blast Crisis, Melanoma, Malignant
How Eldesine works
Eldesine acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase.
Food Interaction
- Exercise caution with grapefruit products. Eldesine is metabolized by CYP3A4, and grapefruit inhibits CYP3A4 metabolism, which may increase vindesine serum levels.
- Exercise caution with St. John's Wort. Eldesine is metabolized by CYP3A4 and this herb induces CYP3A4 metabolism, which may reduce vindesine serum levels.
Half Life
24 hours.
Innovators Monograph
You find simplified version here Eldesine