Ethamide

Ethamide Uses, Dosage, Side Effects, Food Interaction and all others data.

Ethamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.

Ethamide is an inhibitor of the carbonic anhydrase enzyme in proximal renal tubules that works by decreasing the reabsorption of water, sodium, potassium, bicarbonate. It also decreases the activity of carbonic anhydrase expressed in the CNS, which leads to increased seizure threshold. Inhibition of carbonic anhydrase in the eye contributes to its effect of reducing intraocular pressure and decreasing aqueous humor.

Trade Name Ethamide
Generic Ethoxzolamide
Ethoxzolamide Other Names Ethoxazolamide, Ethoxyzolamide
Type
Formula C9H10N2O3S2
Weight Average: 258.317
Monoisotopic: 258.013283576
Protein binding

~89%

Groups Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ethamide
Ethamide

Uses

For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.

How Ethamide works

Ethamide binds to and inhibits carbonic anhydrase I, which plays an essential role in facilitating the transport of CO2 and H+ in the intracellular space, across biological membranes, and in the layers of the extracellular space. Through inhibition of the enzyme, the balance of applicable membrane equilibrium systems are affected.

Elimination Route

Rapidly absorbed with 65% bioavailability

Half Life

2.5-5.5 hours

Innovators Monograph

You find simplified version here Ethamide

*** Taking medicines without doctor's advice can cause long-term problems.
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