Encremin

Encremin Uses, Dosage, Side Effects, Food Interaction and all others data.

Pancreatin is a preparation of Pancreatin having protease, lipase and amylase enzyme activity. Pancreatin hydrolyses fats to glycerol and fatty acids, changes protein into proteoses and derived substances and converts starch into dextrins and sugars. Pancreatin is employed in the conditions where the secretion of pancreatic juice is defcient.

The major maldigestion/malabsorption problems arise from incomplete fat digestion. In clinical trials, the administration of pancrelipase as a mixture of amylase, lipase, and protease demonstrated a significant improvement in the coefficient of fat absorption and nitrogen absorption. These effects are accompanied by increased in body weight and body mass index.

Trade Name Encremin
Availability Rx and/or OTC
Generic Pancrelipase
Pancrelipase Other Names Pancrealipase, Pancreatic extract pancrelipase, Pancreatic protease, Pancreatin, Pancreatinum, Pancrelipase, Pancrelipase (amylase;lipase;protease)
Related Drugs azithromycin, gentamicin, Zithromax, Creon, tobramycin, Zenpep, pancreatin, Pancreaze, Pertzye, Viokace
Type Capsule
Weight 131000.0 Da
Protein binding

Pancrelipase acts locally in the GI tract and it is not absorbed in any significant amount thus, the protein binding is not relevant.

Groups Approved, Investigational
Therapeutic Class Digestive Enzyme
Manufacturer Strides Shasun Limited
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Encremin
Encremin

Uses

Children:

  • Reduced or absence of pancreatic exocrine secretion
  • Cystic fbrosis

Adults:

In the conditions with defcient pancreatic exocrine function such as-

  • Following pancreatectomy
  • Following total gastrectomy
  • Chronic pancreatitis
  • Steatorrhea
  • Somatostatinoma
  • Celiac disease

Encremin is also used to associated treatment for these conditions: Aerophagy, Deficiency Digestive enzymes, Diarrhoea, Dyspepsia, Exocrine Pancreatic Insufficiency, Flatulence, Gastrointestinal Discomfort, Pancreatic Insufficiency, Post Operative Gas, Pre-operative Gas, Fat malabsorption, Meteorism, Bile Duct Disorders, Carbohydrate Digestion, Digestive Aid, Fat Digestion, Liver Metabolism, Protein Digestion

How Encremin works

Encremin is used to replace the deficiency of pancreatic enzymes. As abovementioned, pancrelipase is formed by a mixture of lipase, protease, and amylase which are able to break down fat, protein, and starches, respectively, in the small intestine. For a more specific description of each mechanism of action, please visit Encremin amylase, Encremin protease and Encremin lipase.

Dosage

Encremin dosage

1-3 tablets daily with meal or as per direction of the physician.

Side Effects

Pancreatin may cause buccal and perianal soreness, particularly in infants. Hypersensitivity reactions have been reported; these may be sneezing, lacrimation or skin rashes.

Toxicity

The studies of the toxicology of pancrelipase are not needed as this drug has been used clinically for a long time. Clinical overdose studies proved no effect on lungs, pancreas, liver and kidneys but it can produce symptoms such as diarrhea or stomach upset. Carcinogenicity studies have not shown any increased incidence with the use of pancrelipase. As pancrelipase is not absorbed, the effect on fetal development or reproduction is not expected.

Precaution

A proper balance between fat, protein and starch intake must be maintained to avoid temporary indigestion.

Interaction

Alkaline media will rupture the enteric coating. As such to prevent bursting out of the content in the stomach Pancreatin should not be used concurrently with antacid.

Food Interaction

  • Drink plenty of fluids.
  • Take with fluids.
  • Take with food. If swallowing the oral capsule is not tolerated, sprinkle on acidic soft foods with a pH of 4 or less.

Encremin multivitamins interaction

[Moderate] Exogenous pancreatic enzymes may interfere with the gastrointestinal absorption of folic acid and iron.

The exact mechanism of interaction is unknown.

In one study, investigators compared oral iron absorption over a 3-hour period in the presence and absence of exogenous pancreatic enzymes in 13 stable young adults with cystic fibrosis and 9 age-matched controls.

There was no difference between patients and controls in iron absorption in the absence of exogenous pancreatic enzymes.

However, significant impairment of iron absorption was observed in both groups after administration of pancrelipase one hour prior to iron administration.

In the patient group, one hour after iron administration, there was a 188% increase in serum iron level above baseline in the absence of pancrelipase but only a 62% increase in the presence of pancrelipase.

In the controls, percentage increases as well as peak serum iron levels were significantly higher in the absence of pancrelipase during all 3 hours after iron administration.

Clinically, at least one-third of cystic fibrosis patients reportedly have iron deficiency.

In the study, mean serum iron concentration was significantly lower in patients than in controls (11.9 versus 18.9 micromoles
Patients receiving therapeutic iron or folate therapy should be monitored for potentially reduced hematologic response if pancreatic enzymes are administered concomitantly.

Separating the times of administration may be helpful.

Encremin Disease Interaction

Moderate: hyperuricemia

Volume of Distribution

Encremin acts locally in the GI tract and it is not absorbed in any significant amount thus, the volume of distribution is not relevant.

Elimination Route

Encremin acts locally in the GI tract and it is not absorbed in any significant amount.

Half Life

Encremin acts locally in the GI tract and it is not absorbed in any significant amount thus, the elimination half-life is not relevant.

Clearance

Encremin acts locally in the GI tract and it is not absorbed in any significant amount thus, the clearance rate is not relevant.

Elimination Route

Encremin is entirely eliminated in the feces.

Pregnancy & Breastfeeding use

Pregnancy category C. Not known whether Pancreatin is distributed into milk. Caution advised if Pancreatin is used.

Acute Overdose

Excessive dosage may produce a laxative efect. Systemic toxicity does not occur. Very high dosage may cause hyperuricemia and hyperuricos-uria.

Storage Condition

Store in a cool and dry place. Keep out of the reach of children.

Innovators Monograph

You find simplified version here Encremin

FAQ

What is Encremin used for?

Encremin is used to help improve food digestion in certain conditions where the pancreas is not working properly.

How safe is Encremin?

Encremin is safe and effective in children when taken as prescribed by your doctor.

How does Encremin work?

Encremin works to decrease fatty bowel movements and to improve nutrition by breaking down fats, proteins, and starches from food into smaller substances that can be absorbed from the intestine.

What are the common side effects of Encremin?

Common side effects of Encremin are include:

  • stomach pain, gas, upset stomach;
  • diarrhea, frequent or abnormal bowel movements;
  • rectal itching;
  • headache;
  • runny or stuffy nose, sore throat; or.
  • changes in your blood sugar.

Is Encremin safe during pregnancy?

Encremin should be used during pregnancy only if clearly needed and the benefit outweighs the risk to the fetus.

Is Encremin safe during breastfeeding?

Caution is recommended, benefit to mother should outweigh risk to the infant. The effects in the nursing infant are unknown. Some experts recommend;Encremin should be used in doses sufficient to provide adequate effects to the mother.

When should I take Encremin?

Encremin is taken with plenty of water with every meal or snack, usually 5 to 6 times per day.

How long does it take for Encremin enzymes to work?

Encremin enzymes begin to work fairly immediately after taking them. They continue to work for about an hour to digest the food that has been consumed.

Can I stop taking Encremin enzymes?

Do not stop taking your enzymes if your symptoms persist  try increasing the dose and contact your medical team for help.

Who should not take Encremin?

You should not take Encremin if you are allergic to pork proteins. Call your doctor at once if you have symptoms of a rare but serious bowel disorder: severe or unusual stomach pain, vomiting, bloating, diarrhea, or constipation.

Can Encremin cause pancreatitis?


Kidney disease or Pancreatitis usese with caution. May make these conditions worse.

What happens if I miss a dose of Encremin?

Take the missed dose with your next meal or snack. Do not take two doses at one time.Get your prescription refilled before you run out of medicine completely.

Can I take Encremin long time?

Do not change the dose of your medication unless your doctor tells you that you should. Your doctor will tell you the maximum amount of Encremin you should take in one day. Do not take more than this amount of Encremin in one day even if you eat more than your usual number of meals and snacks.

Can Encremin affect the liver?

Encremin can affects on liver also with other side effects are Gastrointestinal disorders ,skin disorders, blurred vision, myalgia, muscle spasm, and asymptomatic elevations of liver enzymes have been reported with this formulation of Encremin.

How should I store the Encremin?

Keep out of the reach of children.Do not keep outdated medicine or medicine no longer needed.Ask your healthcare professional how you should dispose of any medicine you do not use.

Will I have to take Encremin forever?

If you have had surgery to remove your entire pancreas or if it has been damaged by cancer, you will need to take Encremin for the rest of your life.

Can I take Encremin without food?

Encremin comes as a tablet, and a delayed-release capsule to take by mouth. It is taken with plenty of water with every meal or snack, usually 5 to 6 times per day.

*** Taking medicines without doctor's advice can cause long-term problems.
Share