Ethoxyzolamide

Ethoxyzolamide Uses, Dosage, Side Effects, Food Interaction and all others data.

Ethoxyzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.

Ethoxyzolamide is an inhibitor of the carbonic anhydrase enzyme in proximal renal tubules that works by decreasing the reabsorption of water, sodium, potassium, bicarbonate. It also decreases the activity of carbonic anhydrase expressed in the CNS, which leads to increased seizure threshold. Inhibition of carbonic anhydrase in the eye contributes to its effect of reducing intraocular pressure and decreasing aqueous humor.

Ethoxyzolamide
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Ethoxyzolamide
Generic	Ethoxzolamide
Ethoxzolamide Other Names	Ethoxazolamide, Ethoxyzolamide
Type
Formula	C₉H₁₀N₂O₃S₂
Weight	Average: 258.317 Monoisotopic: 258.013283576
Protein binding	~89%
Groups	Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.

How Ethoxyzolamide works

Ethoxyzolamide binds to and inhibits carbonic anhydrase I, which plays an essential role in facilitating the transport of CO2 and H+ in the intracellular space, across biological membranes, and in the layers of the extracellular space. Through inhibition of the enzyme, the balance of applicable membrane equilibrium systems are affected.