Ethyl Methylglyoxylate
Ethyl Methylglyoxylate Uses, Dosage, Side Effects, Food Interaction and all others data.
CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia.
| Trade Name | Ethyl Methylglyoxylate |
| Generic | Ethyl pyruvate |
| Ethyl pyruvate Other Names | Ethyl 2-oxopropanoate, Ethyl 2-oxopropionate, Ethyl methylglyoxylate, Pyruvic acid ethyl ester, Pyruvic acid, ethyl ester |
| Type | |
| Formula | C5H8O3 |
| Weight | Average: 116.1152 Monoisotopic: 116.047344122 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia.
How Ethyl Methylglyoxylate works
CTI-01 inhibits the systemic release of cytokines, such as TNF-alpha and HMGB1, which promote the body's inflammatory response. The over-expression of these cytokines has been linked to diseases that occur in critical care settings, such as severe organ damage following cardiopulmonary bypass (CPB) and post-operative ileus following abdominal surgery.
Innovators Monograph
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