Fibrase
Fibrase Uses, Dosage, Side Effects, Food Interaction and all others data.
Fibrase is a sulfated pentosyl polysaccharide with heparin-like properties.
Fibrase sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.
| Trade Name | Fibrase |
| Generic | Pentosan polysulfate |
| Pentosan polysulfate Other Names | Pentosan polysulfate, Pentosan sulfuric polyester, Pentosane polysulfate, Pentosani polysulfas, Pentosano polisulfato, Pentosanpolysulfat |
| Type | |
| Formula | C10H18O21S4 |
| Weight | Average: 602.497 Monoisotopic: 601.922340398 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fibrase is a sulfated pentosyl polysaccharide used to treat bladder pain and discomfort due to interstitial cystitis.
For the relief of bladder pain or discomfort associated with interstitial cystitis.
Fibrase is also used to associated treatment for these conditions: Cystitis interstitial
How Fibrase works
Fibrase is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking pentosan polysulfate with anticoagulant herbs may increase bleeding risk, which is an adverse effect of pentosan polysulfate.
- Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
Elimination Route
Slow
Half Life
4.8 hours
Innovators Monograph
You find simplified version here Fibrase
