Fibrolan

Fibrolan Uses, Dosage, Side Effects, Food Interaction and all others data.

Fibrolan consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of Fibrolan; the heavy chain has a molecular weight of approximately 57,000 Da. Fibrolan is used as a local healing ointment when combined together with the enzyme deoxyribonuclease I (extracted from bovine pancreas). Fibrolan and deoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) Fibrolan and 666 BUs desoxyribonuclease per gram. The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries (e.g. Switzerland). It is currently not approved in the USA.

Fibrolan
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Fibrolan
Generic	Fibrinolysin
Fibrinolysin Other Names	Bovine Fibrinolysin, Bovine Plasmin, Fibrinolysin (human), Fibrinolysin, human, Plasmin (bos taurus), Plasmin (bovine), Plasmin bovine
Type
Formula	C₃₈₄₈H₅₉₁₂N₁₀₉₆O₁₁₈₅S₆₀
Weight	88411.4 Da
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fibrolan assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.

How Fibrolan works

Fibrolan attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue.