Fibrovein
Fibrovein Uses, Dosage, Side Effects, Food Interaction and all others data.
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Fibrovein is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.
| Trade Name | Fibrovein |
| Generic | Sodium tetradecyl sulfate |
| Sodium tetradecyl sulfate Other Names | Natrii tetradecylis sulfa, Sodium tetradecyl sulfate, Sodium tetradecyl sulphate, Sodium tetradecylsulfate, Tetradecilsulfato sodico, Tetradecyl sodium sulfate, Tetradecyl sulfate de sodium |
| Type | Injection |
| Formula | C14H29NaO4S |
| Weight | Average: 316.43 Monoisotopic: 316.16842487 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | STD Pharmaceutical Products Ltd |
| Available Country | United Kingdom, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fibrovein is an anionic surfactant used to treat varicose veins of the lower extremities.
For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
Fibrovein is also used to associated treatment for these conditions: Uncomplicated Varicose vein
How Fibrovein works
Fibrovein is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.
Toxicity
LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat)
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here Fibrovein
