Floral Forte

Uses

Fluorometholone Acetate ophthalmic suspension is used for the treatment of-

• Acute and chronic non-infectious conjunctivitis and keratitis of allergic origin.
• Non-infectious inflammation of the anterior chamber of the eye (including anterior uveitis, episcleritis and scleritis).
• Post-operative irritative conditions after strabismus, cataract and glaucoma surgery.

Polyvinyl alcohol is a compound used as an ophthalmic lubricant.

For use as a lubricant to prevent further irritation or to relieve dryness of the eye(s) .

Floral Forte is also used to associated treatment for these conditions: Anterior chamber inflammation, Conjunctivitis allergic, Corneal Inflammation, Inflammation, Ocular Inflammation, Ocular bacterial infectionsDry Eyes, Eye lubrication

How Floral Forte works

There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.

As a synthetic resin with hydrophilic properties, it increases the persistence of tear film and therefore lubricates and soothes dry/irritated eyes .

Dosage

Floral Forte dosage

1 drop instilled into the conjunctival sac 2-4 times daily. During the initial 24 to 48 hours the dosage may be safely increased to 1 drop every hour. Care should be taken not to discontinue therapy prematurely. Shake well before use.

Side Effects

Glaucoma with optic nerve damage, visual acuity or field defects, cataract formation, secondary ocular infection following suppression of host immunity, perforation of the globe.

Toxicity

Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD₅₀ = 234 mg/kg (rats)

The oral acute toxicity of PVOH (LD50) in rats and mice are 20 g/kg and 14.7 g/kg, respectively . Adverse effects include eye pain and changes of vision, and redness or irritation of the eye .

Mild stinging or irritation of the eye, crusting of eyelid, eye pain, ocular hyperaemia, eye pruritus, foreign body sensation, eye discharge, and increased lacrimation may also occur .

Precaution

Shake well before using. If this product is used for 10 days or longer, intraocular pressure should be monitored.

Interaction

Specific drug interaction studies have not been conducted with Fluorometholone ophthalmic suspension.

Volume of Distribution

This drug does not accumulate in the body when administered orally .

Elimination Route

Polyvinyl alcohol is poorly absorbed from gastrointestinal tract, and readily eliminated from the body .

Half Life

When injected intravenously, polyvinyl alcohol has a half-life of 90 min .

Intraocularly, in eye drop form, the half-life is 7.2 minutes .

Pregnancy & Breastfeeding use

Safety of the use of topical steroids during pregnancy and lactation has not been established. Fluorometholone ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Contraindication

• Hypersensitivity to any ingredient of the formulation.
• Infectious conjunctivitis or keratitis.
• Injuries and ulcerous processes of cornea, especially infections caused by virus, bacteria and fungi.
• Dry eyes, especially keratoconjunctivitis sicca.
• Glaucoma.

Storage Condition

Store in a cool, dry place and protected from light. Keep out of the reach of children. Discard the container 4 weeks after opening.

Innovators Monograph

You find simplified version here Floral Forte