Gabrene

Gabrene Uses, Dosage, Side Effects, Food Interaction and all others data.

Gabrene is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. In clinical trials, progabide has been investigated for Parkinson's disease, schizophrenia, clinical depression and anxiety disorder; its therapeutic effectiveness in these conditions is not fully elucidated.

Gabrene, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.

Trade Name Gabrene
Generic Progabide
Progabide Other Names Halogabide, Progabida, Progabide, Progabidum
Type
Formula C17H16ClFN2O2
Weight Average: 334.78
Monoisotopic: 334.0884336
Protein binding

95%

Groups Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Gabrene
Gabrene

Uses

Indicated for the treatment of epilepsy.

How Gabrene works

Gabrene binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABAB receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters.

Elimination Route

Well absorbed with a bioavailability of 60%

Half Life

4 hours

Innovators Monograph

You find simplified version here Gabrene

*** Taking medicines without doctor's advice can cause long-term problems.
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