Gabrene

Gabrene Uses, Dosage, Side Effects, Food Interaction and all others data.

Gabrene is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. In clinical trials, progabide has been investigated for Parkinson's disease, schizophrenia, clinical depression and anxiety disorder; its therapeutic effectiveness in these conditions is not fully elucidated.

Gabrene, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.

Gabrene
Uses
Dosage
Side Effect
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Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Gabrene
Generic	Progabide
Progabide Other Names	Halogabide, Progabida, Progabide, Progabidum
Type
Formula	C₁₇H₁₆ClFN₂O₂
Weight	Average: 334.78 Monoisotopic: 334.0884336
Protein binding	95%
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Indicated for the treatment of epilepsy.

How Gabrene works

Gabrene binds to both GABA_A and GABA_B receptors located on the terminals of primary afferent fibers. Binding to GABA_A results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABA_B receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters.