Gastrochinolon
Gastrochinolon Uses, Dosage, Side Effects, Food Interaction and all others data.
Gastrochinolon is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Gastrochinolon is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Trade Name | Gastrochinolon |
Generic | Finafloxacin |
Finafloxacin Other Names | Finafloxacin, gastrochinolon, gastroquinolone |
Type | |
Formula | C20H19FN4O4 |
Weight | Average: 398.394 Monoisotopic: 398.139033271 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gastrochinolon is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.
Gastrochinolon is also used to associated treatment for these conditions: Acute Otitis Externa
How Gastrochinolon works
Gastrochinolon is a fluoroquinolone antibiotic, which selectively inhibit bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination.
Toxicity
-Gastrochinolon was shown to be genotoxic and clastogenic in vitro, with and without metabolic activation, and in vivo. -General toxicity studies in rats have confirmed sperm toxicity following oral and intravenous dosing. -At 500 mg/kg/day, males were completely infertile, presumably due to low sperm count and sperm immobility.
Innovators Monograph
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