Genaton

Genaton Uses, Dosage, Side Effects, Food Interaction and all others data.

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach .

Neutralizes acid in the stomach .

Table Of contents

• Genaton
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Genaton
Generic	Aluminum hydroxide + magnesium carbonate
Weight	254mg + 237.5mg/5ml, 95mg + 358mg/15ml, 160mg + 105mg
Type	Oral suspension, oral tablet, chewable
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Aluminum hydroxide is an antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.

For relief of heartburn and acid indigestion.

Magnesium carbonate is an antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.

Used as an over the counter antacid .

Genaton is also used to associated treatment for these conditions: Abdominal Pain, Acid Reflux, Acid Regurgitation, Acid indigestion, Anginal Pain caused by Gas, Bloating, Colic, Duodenal Ulcer, Dyspepsia, Flatulence, Gastric Ulcer, Gastroesophageal Reflux, Heartburn, Hyperphosphataemia, Pain, Inflammatory, Skin Irritation, Upset stomach, Stomach pains caused by Gastric Acid, Gastric Acid SuppressionAcid indigestion, Bladder calculus, Heartburn, Kidney Stones, Upset stomach, Catheter irrigation

How Genaton works

Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins.

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach .

Toxicity

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia .

Volume of Distribution

Vd for magnesium is 0.2-0.4L/kg . About 50% distributes to bone.

Elimination Route

Approximately 17-30% of the aluminum chloride formed is absorbed.

About 40-60% of magnesium is absorbed following oral administration . Percent absorption decreases as dose increases.

Half Life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult .

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance .

Elimination Route

Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.

Primarily eliminated in urine .

Innovators Monograph

You find simplified version here Genaton