Genpram D

Genpram D Uses, Dosage, Side Effects, Food Interaction and all others data.

Genpram D is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.

Genpram D is a blood schizonticide active against erythrocytic stages of Plasmodium falciparum. It is thought that administration of lumefantrine with artemether results in cooperate antimalarial clearing effects. Artemether has a rapid onset of action and is rapidly cleared from the body. It is thus thought to provide rapid symptomatic relief by reducing the number of malarial parasites. Genpram D has a much longer half life and is believed to clear residual parasites.

Genpram D
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Genpram D
Generic	Lumefantrine
Lumefantrine Other Names	Benflumetol, dl-Benflumelol, Lumefantrine
Weight	10mg
Type	Tablet
Formula	C₃₀H₃₂Cl₃NO
Weight	Average: 528.94 Monoisotopic: 527.154947772
Protein binding	99.7% bound
Groups	Approved
Therapeutic Class
Manufacturer	Genome Pharmaceuticals (pvt) Ltd
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Genpram D is an antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.

Genpram D and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.

Genpram D is also used to associated treatment for these conditions: Uncomplicated Malaria caused by Plasmodium falciparum

How Genpram D works

The exact mechanism by which lumefantrine exerts its antimalarial effect is unknown. However, available data suggest that lumefantrine inhibits the formation of β-hematin by forming a complex with hemin and inhibits nucleic acid and protein synthesis.

Toxicity

Common side effects of combination artemether/lumefantrine therapy in adults include headache, anorexia, dizziness, and asthenia. Common side effects in children include pyrexia, cough, vomiting, anorexia, and headache. Possible serious adverse effects include QT prolongation, bullous eruption, urticaria, splenomegaly (9%), hepatomegaly (adults, 9%; children, 6%), hypersensitivty reaction, and angioedema.