Gentian Violet(1+)
Gentian Violet(1+) Uses, Dosage, Side Effects, Food Interaction and all others data.
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
Gentian violet is a mutagen, a mitotic poison, and a clastogen. Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as a topical antibiotic, as a topical antifungal agent, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. It is thought to work by binding to the DNA of target organisms and causing disruption, mutation or inhibition of DNA replication.
| Trade Name | Gentian Violet(1+) |
| Generic | Gentian violet cation |
| Gentian violet cation Other Names | Crystal Violet, Crystal violet(1+), Gentian violet cation, Gentian violet(1+), Methylrosaniline, Methylrosanilinium, Gentian Violet |
| Type | |
| Formula | C25H30N3 |
| Weight | Average: 372.5258 Monoisotopic: 372.243972975 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gentian Violet is an antiseptic violet dye used to prevent various infections, including fungal and bacterial infections.
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive).
Gentian Violet(1+) is also used to associated treatment for these conditions: Bacterial Infection of the umbilical cord area, Fungal Infection of the umbilical cord area, Infection, Infections, Fungal
How Gentian Violet(1+) works
In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Toxicity
LD50=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
Food Interaction
No interactions found.Innovators Monograph
You find simplified version here Gentian Violet(1+)
