Glutethimid

Glutethimid Uses, Dosage, Side Effects, Food Interaction and all others data.

Glutethimid is a hypnotic and sedative. Its use has been largely superseded by other drugs.

Glutethimid, like the barbiturates, is a hypnotic sedative. It was introduced in 1954 as a safer alternative to barbiturates but was soon determined to be just as likely to cause addiction and withdrawal symptoms.

Glutethimid
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Glutethimid
Generic	Glutethimide
Glutethimide Other Names	Glutethimide, Glutetimida
Type
Formula	C₁₃H₁₅NO₂
Weight	Average: 217.2637 Monoisotopic: 217.110278729
Groups	Approved, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of insomnia.

How Glutethimid works

Glutethimid seems to be a GABA agonist which helps induce sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of codeine (higher than the average 5 - 10%) to morphine. This combination of effects enhances sedation.

Toxicity

In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.

Food Interaction

Avoid alcohol.
Take with or without food. The absorption is unaffected by food.

Elimination Route

Variable

Half Life

10-12 hours

Elimination Route

glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.