Glycylhistidyllysine

Glycylhistidyllysine Uses, Dosage, Side Effects, Food Interaction and all others data.

Glycylhistidyllysine is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Glycylhistidyllysine is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated.

Glycylhistidyllysine in complex with copper improve skin elasticity, density, and firmness, reduces fine lines and wrinkles, reduces photodamage, increases keratinocyte proliferation . Glycylhistidyllysine also displays anti-oxidant and angiogenic effects and appears to modulate tissue remodeling in injury.

Glycylhistidyllysine
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Uses during Pregnancy
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Trade Name	Glycylhistidyllysine
Generic	Prezatide
Prezatide Other Names	Gly-His-Lys, Glycylhistidyllysine, Liver cell growth factor, Tripeptide-1
Type
Formula	C₁₄H₂₄N₆O₄
Weight	Average: 340.384 Monoisotopic: 340.185903277
Groups	Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Commonly used in cosmetic products for the skin and hair .

How Glycylhistidyllysine works

Glycylhistidyllysine in complex with copper increases the synthesis and deposition of type I collagen and glycosaminoglycan . It also increases the expression of matrix metalloproteinase-2 as well as tissue inhibitor of matrix metalloproteinases-1 and -2, suggesting that it plays a role in the modulation of tissue remodeling . It is thought that prezatide's antioxidant activity is due to its ability to supply copper for superoxide dismutase and its anti inflammatory ability due to the blockage the of iron (Fe2+) release during injury . Glycylhistidyllysine also increases angiogenesis to injury sites. The precise mechanisms of these effects are unknown. It is also unknown whether prezatide's effects are due to the action of the tripeptide itself or its ability to localize and transport copper . Glycylhistidyllysine is known to be bound by heparin and heparin sulfate

Elimination Route

Glycylhistidyllysine both free and in complex with copper can pass through the stratum corneum . Its absorption is pH dependent with the highest absorption occurring at physiological pH.