Halotano
Halotano Uses, Dosage, Side Effects, Food Interaction and all others data.
When inhaled, Halotano is absorbed through the alveoli into the bloodstream. In the bloodstream, Halotano circulates through the body to the principal site of action, the brain. Here Halotano causes a progressive depression of the central nervous system, beginning with the higher centers (cerebral cortex) and spreading to the vital centers in the medulla. This depression is reversible. However, its mode of action, like all anaesthetic agents, is unknown.
Halotano has a relatively low solubility in blood and therefore alveoli/blood concentrations equilibrate rapidly. The triexponential decline in Halotano blood concentrations following the end of administration is thought to represent distribution into three compartments; the vessel rich group (brain/heart/liver), the musculature and adipose tissue. Approximately 80% of the inhaled Halotano is eliminated unchanged by the lungs. The remaining 20% is metabolized in the liver by oxidative and under hypoxic conditions, reductive pathways. The main metabolites are trifluoroacetic acid, bromide and chloride salts (via the oxidative pathway) and fluoride salts (via the reductive pathway). The concentrations of metabolites peak 24 hours post-operatively and are eliminated by renal excretion during the following week.
Halotano is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
| Trade Name | Halotano |
| Availability | Discontinued |
| Generic | Halothane |
| Halothane Other Names | Alotano, Bromochlorotrifluoroethane, Halotano, Halothane, Halothanum |
| Related Drugs | fentanyl, lidocaine, ketamine, hyoscyamine, propofol, glycopyrrolate |
| Type | |
| Formula | C2HBrClF3 |
| Weight | Average: 197.382 Monoisotopic: 195.890225001 |
| Groups | Approved, Vet approved |
| Therapeutic Class | General (Inhalation) anesthetics |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Halotano is a volatile anaesthetic which is suitable for the induction and maintenance of anaesthesia for all types of surgery and in patients of all ages.
Halotano is also used to associated treatment for these conditions: Anaesthesia therapy
How Halotano works
Halotano causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halotano's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization.
Dosage
Halotano dosage
A number of anaesthetic vaporisers specially designed for use with Halotano are available. Open, semi-open, semi-closed and closed circuit systems have all been used with good results.
For induction of anaesthesia:
- Adult: A concentration of 2-4% Halotano in Oxygen or Nitrous Oxide may be used.
- Children: A concentration of 1.5-2% Halotano in Oxygen or Nitrous Oxide is used.
For maintenance of anaesthesia:
- Adults and children: A concentration of 0.5-2% is usually required for maintenance of anaesthesia. The lower concentration is usually most suitable for elderly patients.
Side Effects
Post-op nausea, vomiting, and shivering; resp depression, hypotension, skeletal muscle relaxation, bradycardia.
Toxicity
Toxic effects of halothane include malignant hyperthermia and hepatitis.
Precaution
Caution should be exercised during administration of adrenaline to patients anaesthetised with Halotano as dysrhythmias may be precipitated. For this reason the dose of adrenaline should be restricted and beta-receptor antagonists administered if necessary. Ensure adequate room ventilation when Halotano is being used. Keep the concentration of Halotano in air as low as possible.
Effect on ability to drive or operate machinery: Patients should be advised that performance at skilled tasks, such as driving and operating machinery, may be impaired for some time after general anaesthesia.
Accidental ingestion: Cases of ingestion must be treated symptomatically.
Interaction
Increased risk of ventricular dysrhythmias with epinephrine. Increased risk of malignant hyperthermia with suxamethonium. Prolonged recovery from anaesth with concurrent use of ketamine for induction. May potentiate response to non-depolarising muscle relaxants, hypotensive agents (e.g. hexamethonium bromide, trimetaphan camsilate).
Food Interaction
No interactions found.Halotano Drug Interaction
Unknown: aspirin, aspirin, dexamethasone, dexamethasone, dextran, low molecular weight, dextran, low molecular weight, ginkgo, ginkgo, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, riboflavin, riboflavin, pyridoxine, pyridoxine, ascorbic acid, ascorbic acid, phytonadione, phytonadione
Halotano Disease Interaction
Pregnancy & Breastfeeding use
Category C: Although the data from experimental investigations in animals cannot be directly related to man, it would be prudent to avoid general anaesthesia with inhalation agents during early pregnancy, except where such use is essential.
Lactation: There are no well controlled studies with Halotano in lactating women. Halotano has been detected in breast milk of lactating women, but the effect of Halotano on breast feed neonates has not been established. However, Halotano has been in wide use for over 30 years without apparent ill consequence
Contraindication
Halotano can induce liver damage; however, the incidence of severe liver damage (jaundice, which may lead to hepatic failure as a consequence of massive hepatic cell necrosis) is unknown. The risk of developing hepatic failure appears to be increased by repeated exposure. Although short intervals of time between exposures are likely to increase the risk of hepatotoxicity, even long intervals between exposures maynot eliminate the risks, since some patients have developed severe reactions following Halotano given many years after the previous exposures. On the information which is available at the present time, it is advised that the followingprecautions be taken
- A careful anaesthetic history should be taken prior to use, to determine previous exposure and previous reactions following Halotano anaesthesia.
- Repeated exposure to Halotano within a period of at least 3 months should be avoided unless there are overriding clinical circumstances.
- History of unexplained jaundice and pyrexia in a patient following exposure to
- Halotano is a contraindication to its future use in that patient unless absolutely essential.
- Patients should be informed if they have developed a reaction possibly related to Halotano anaesthesia; such patients should be provided with a medical alert card stating the problem.
Storage Condition
Bottles of Halotano must be securely closed and stored in a cool dry place, protected from light. Halotano must be kept in the original container until immediately prior to its use.
Whilst in the liquid phase, Halotano must not be diluted or contaminated; however, in the vapour phase it may be administered together with Oxygen or a mixture of Nitrous Oxide and Oxygen.
Innovators Monograph
You find simplified version here Halotano
