Heptabarbitone
Heptabarbitone Uses, Dosage, Side Effects, Food Interaction and all others data.
Heptabarbitone is an intermediate or short term barbiturate used mainly for sedation and hypnosis.
| Trade Name | Heptabarbitone |
| Generic | Heptabarbital |
| Heptabarbital Other Names | Heptabarb, Heptabarbe, Heptabarbital, Heptabarbitone, Heptabarbo, Heptabarbum |
| Type | |
| Formula | C13H18N2O3 |
| Weight | Average: 250.2936 Monoisotopic: 250.131742452 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used mainly for sedation and hypnosis.
How Heptabarbitone works
Heptabarbitone (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Heptabarbitone also appears to bind neuronal nicotinic acetylcholine receptors.
Toxicity
Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Innovators Monograph
You find simplified version here Heptabarbitone
