Hexachlorophene

Hexachlorophene Uses, Dosage, Side Effects, Food Interaction and all others data.

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)

Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.

Trade Name Hexachlorophene
Generic Hexachlorophene
Hexachlorophene Other Names hexachlorophène, Hexachlorophene, Hexachlorophenum, Hexaclorofeno
Type Topical application
Formula C13H6Cl6O2
Weight Average: 406.904
Monoisotopic: 403.849895678
Protein binding

92%

Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Hexachlorophene
Hexachlorophene

Uses

Hexachlorophene is a chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.

For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.

Hexachlorophene is also used to associated treatment for these conditions: Bacterial Infections, Antibiotic pre-surgical prophylaxis, Prophylaxis of bacterial skin infections

How Hexachlorophene works

The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.

Toxicity

Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.

Food Interaction

No interactions found.

Elimination Route

Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.

Innovators Monograph

You find simplified version here Hexachlorophene

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5693
http://www.hmdb.ca/metabolites/HMDB0014894
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http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31712
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=5293
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=5693
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL496
https://zinc.docking.org/substances/ZINC000001530968
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001050
http://www.pharmgkb.org/drug/PA449871
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/H3P
http://www.rxlist.com/cgi/generic2/hexchlorph.htm
https://www.drugs.com/cdi/hexachlorophene.html
https://en.wikipedia.org/wiki/Hexachlorophene
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