Histex Pd Drops
Histex Pd Drops Uses, Dosage, Side Effects, Food Interaction and all others data.
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Histex Pd Drops, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Histex Pd Drops has anticholinergic and sedative effects.
Trade Name | Histex Pd Drops |
Availability | Discontinued |
Generic | Triprolidine |
Triprolidine Other Names | Tripolidina, Triprolidin, Triprolidina, Triprolidine, Triprolidinum |
Related Drugs | prednisone, hydroxyzine, cetirizine ophthalmic, cetirizine, loratadine, fluticasone nasal, dexamethasone ophthalmic, promethazine, Zyrtec, prednisolone ophthalmic |
Weight | 0.313mg/ml, 0.625mg/ml, 0.938mg/ml, 1.25mg/ml, 2.5mg/5ml, 1.25mg |
Type | Oral liquid, oral tablet, chewable |
Formula | C19H22N2 |
Weight | Average: 278.3914 Monoisotopic: 278.178298714 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | United States |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Histex Pd Drops is a sedating antihistamine combined with pseudoephedrine and guaifenesin in various types of cold and allergy medications to relieve allergy symptoms, hay fever and common cold symptoms, and to aid in sleep.
For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.
Histex Pd Drops is also used to associated treatment for these conditions: Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Conjunctivitis, Seasonal Allergic Rhinitis, Upper respiratory tract signs and symptoms, Vasomotor Rhinitis, Mild Angioedema, Mild urticaria, Upper respiratory discomfort
How Histex Pd Drops works
Histex Pd Drops binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Toxicity
Symptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
Food Interaction
- Avoid alcohol. Taking with alcohol may increase drowsiness.
[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.
Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.
Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Histex Pd Drops Drug Interaction
Moderate: contained in alcoholic beverages , diphenhydramine, duloxetine, ethanol, escitalopram, tramadolUnknown: aspirin, pseudoephedrine / triprolidine, dexamethasone, omega-3 polyunsaturated fatty acids, glycerin, arginine, acetaminophen, thiamine, cyanocobalamin, pyridoxine, ascorbic acid, cholecalciferol, phytonadione, zinc sulfate
Histex Pd Drops Disease Interaction
Moderate: anticholinergic effects, asthma/COPD, cardiovascular, renal/liver disease
Elimination Route
Rapidly absorbed in the intestinal tract.
Half Life
4 to 6 hours.
Innovators Monograph
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