Holmium Ho-166 DOTMP
Holmium Ho-166 DOTMP Uses, Dosage, Side Effects, Food Interaction and all others data.
Holmium Ho-166 DOTMP is used in skeletal targeted radiotherapy (STR). SRT is designed to be used in combination with high-dose chemotherapy producing a direct therapeutic effect on the tumor sites in the bone plus a general bone-marrow effect to destroy myeloma cells in the bone marrow. It is an experimental therapy that is being developed by NeoRx Corporation.
| Trade Name | Holmium Ho-166 DOTMP |
| Generic | DOTMP HO-166 |
| DOTMP HO-166 Other Names | 166Ho-DOTMP, Holmium Ho-166 DOTMP |
| Type | |
| Formula | C12H30HoN4O12P4 |
| Weight | Average: 712.215 Monoisotopic: 712.013351681 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in multiple myeloma.
How Holmium Ho-166 DOTMP works
There are two important components of 166Ho-DOTMP. The first is DOTMP, a chemical that collects in bones. The other component of 166Ho-DOTMP is radioactive holmium, abbreviated 166Ho. 166Ho is a radioactive particle that is bound to the DOTMP. Certain types of cells in the body, such as many cancer cells, are sensitive to radioactivity and can be killed if they are close to a radioactive particle such as 166Ho. These properties make 166Ho-DOTMP a potentially useful drug for the treatment of cancers in the bone. When the drug collects in the bone, it will expose cells there to 166Ho, killing cancer cells.
Innovators Monograph
You find simplified version here Holmium Ho-166 DOTMP
