Ilomedine
Ilomedine Uses, Dosage, Side Effects, Food Interaction and all others data.
Ilomedine is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Ilomedine is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.
Trade Name | Ilomedine |
Availability | Prescription only |
Generic | Iloprost |
Iloprost Other Names | Iloprost |
Related Drugs | sildenafil, tadalafil, Revatio, Adempas, Opsumit, ambrisentan |
Type | |
Formula | C22H32O4 |
Weight | Average: 360.494 Monoisotopic: 360.23005951 |
Protein binding | 60% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | France, Netherlands |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ilomedine is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
Used for the treatment of pulmonary arterial hypertension.
Ilomedine is also used to associated treatment for these conditions: NYHA class III Pulmonary arterial hypertension, NYHA class IV Pulmonary arterial hypertension
How Ilomedine works
Ilomedine is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. Ilomedine binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. Ilomedine constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. Ilomedine inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension.
Toxicity
Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking iloprost with anticoagulant/antiplatelet herbs may increase the risk of bleeding occurring as an adverse effect. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
Ilomedine Drug Interaction
Moderate: aspirin, aspirin, epinephrine, epinephrine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: charcoal, charcoal, amoxicillin / clavulanate, amoxicillin / clavulanate, Allergy , Allergy , ubiquinone, ubiquinone, glucose, glucose, sodium iodide, sodium iodide, acetaminophen, acetaminophen
Ilomedine Disease Interaction
Volume of Distribution
- 0.7 to 0.8 L/kg
Elimination Route
Rapidly absorbed with bioavailability of 63%
Half Life
20-30 minutes
Clearance
- 20 mL/min/kg [Normal subjects]
Innovators Monograph
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