Iloprost Inhalation

Iloprost Inhalation Uses, Dosage, Side Effects, Food Interaction and all others data.

Iloprost Inhalation is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).

Iloprost Inhalation is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.

Table Of contents

• Iloprost Inhalation
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Iloprost Inhalation
Availability	Prescription only
Generic	Iloprost
Iloprost Other Names	Iloprost
Related Drugs	sildenafil, tadalafil, Revatio, Adempas, Opsumit, ambrisentan
Weight	10mcg/ml, 20mcg/ml
Type	Inhalation solution
Formula	C22H32O4
Weight	Average: 360.494 Monoisotopic: 360.23005951
Protein binding	60%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Iloprost Inhalation is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).

Used for the treatment of pulmonary arterial hypertension.

Iloprost Inhalation is also used to associated treatment for these conditions: NYHA class III Pulmonary arterial hypertension, NYHA class IV Pulmonary arterial hypertension

How Iloprost Inhalation works

Iloprost Inhalation is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. Iloprost Inhalation binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. Iloprost Inhalation constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. Iloprost Inhalation inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension.

Toxicity

Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.

Food Interaction

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking iloprost with anticoagulant/antiplatelet herbs may increase the risk of bleeding occurring as an adverse effect. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Iloprost Inhalation Drug Interaction

Moderate: aspirin, aspirin, epinephrine, epinephrine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: charcoal, charcoal, amoxicillin / clavulanate, amoxicillin / clavulanate, Allergy , Allergy , ubiquinone, ubiquinone, glucose, glucose, sodium iodide, sodium iodide, acetaminophen, acetaminophen

Iloprost Inhalation Disease Interaction

Major: hypotensionModerate: bronchospasm

Volume of Distribution

• 0.7 to 0.8 L/kg

Elimination Route

Rapidly absorbed with bioavailability of 63%

Half Life

20-30 minutes

Clearance

• 20 mL/min/kg [Normal subjects]

Innovators Monograph

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