imukin
imukin Uses, Dosage, Side Effects, Food Interaction and all others data.
Human imukin (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography.The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, imukin may prevent excessive scarring.
| Trade Name | imukin |
| Generic | Interferon gamma-1b |
| Interferon gamma-1b Other Names | IFN-gamma 1b, IFN-gamma-1b, Interferon gamma 1-b, Interferon gamma-1b, Interferon gamma-1b, recombinant, Interferon gamma-2a |
| Weight | 2000000iu, |
| Type | Solution |
| Formula | C761H1206N214O225S6 |
| Weight | 17145.6 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Boehringer Ingelheim, Lda |
| Available Country | Saudi Arabia, Portugal |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
imukin is a form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis.
imukin is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
imukin is also used to associated treatment for these conditions: Chronic Granulomatous Disease (CGD), Severe, malignant Osteopetrosis
How imukin works
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
Food Interaction
- Avoid excessive or chronic alcohol consumption. imukin may cause fatigue, drowsiness, and confusion. These effects may be exacerbated by alcohol consumption.
Innovators Monograph
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