Indecainida
Indecainida Uses, Dosage, Side Effects, Food Interaction and all others data.
Indecainida is a rarely used antidysrhythmic. Indecainida has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
| Trade Name | Indecainida |
| Generic | Indecainide |
| Indecainide Other Names | Indecainida, Indecainide, Indecainidum |
| Type | |
| Formula | C20H24N2O |
| Weight | Average: 308.4174 Monoisotopic: 308.1888634 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.
How Indecainida works
Indecainida acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Toxicity
When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
Elimination Route
Nearly complete following oral administration.
Innovators Monograph
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