Indium-111 Satumomab Pendetide Uses, Dosage, Side Effects and more
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.
| Trade Name | Indium-111 Satumomab Pendetide |
| Generic | Indium In-111 satumomab pendetide |
| Indium In-111 satumomab pendetide Other Names | Indium (111In) satumomab pendetide, Indium In 111 satumomab pendetide, Indium-111 satumomab pendetide |
| Type | |
| Formula | C6268H9708N1666O1971S48 |
| Weight | 141478.9 Da |
| Groups | Experimental, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
For diagnosis of extrahepatic malignant cancers
How Indium-111 Satumomab Pendetide works
Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Half Life
0.8 hours (mammalian reticulocytes, in vitro)
