Indium (111In) Satumomab Pendetide

Indium (111In) Satumomab Pendetide Uses, Dosage, Side Effects, Food Interaction and all others data.

Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.

Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.

Table Of contents

• Indium (111In) Satumomab Pendetide
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Indium (111In) Satumomab Pendetide
Generic	Indium In-111 satumomab pendetide
Indium In-111 satumomab pendetide Other Names	Indium (111In) satumomab pendetide, Indium In 111 satumomab pendetide, Indium-111 satumomab pendetide
Type
Formula	C6268H9708N1666O1971S48
Weight	141478.9 Da
Groups	Experimental, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For diagnosis of extrahepatic malignant cancers

How Indium (111In) Satumomab Pendetide works

Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.

Half Life

0.8 hours (mammalian reticulocytes, in vitro)

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