Ioflupane (123I)

Ioflupane (123I) Uses, Dosage, Side Effects, Food Interaction and all others data.

Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.

iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters.

Trade Name Ioflupane (123I)
Generic Ioflupane I-123
Ioflupane I-123 Other Names 123I-FP-CIT, 123I-Ioflupane, Iodine ioflupane (123I), Ioflupane (123I), Ioflupane I 123, Ioflupane I(123), Ioflupano (123I), Ioflupanum (123I)
Type
Formula C18H23FINO2
Weight Average: 427.291
Monoisotopic: 427.076880092
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ioflupane (123I)
Ioflupane (123I)

Uses

Ioflupane (123I) is a radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.

Ioflupane (123I) is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.

Ioflupane (123I) is also used to associated treatment for these conditions: Parkinsonian Syndromes

How Ioflupane (123I) works

Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT.

Food Interaction

  • Take with or without food.

Volume of Distribution

Compared to the entire brain, about 30% of radioactivity is taken up by the striatum.

Elimination Route

Absorption is 100% because administered I.V.

Half Life

Half life is 13.2 hours.

Elimination Route

About 60% is excreted in the urine and 14% in the feces after 48 hours.

Innovators Monograph

You find simplified version here Ioflupane (123I)

*** Taking medicines without doctor's advice can cause long-term problems.
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