Isoetarinum
Isoetarinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Isoetarinum is a selective adrenergic beta-2 agonist used as fast acting bronchodilator for emphysema, bronchitis and asthma.
Isoetarinum is a relatively selective beta2-adrenergic bronchodilator. Isoetarinum is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. Adrenergic bronchodilators are breathed in through the mouth to open up the bronchial tubes (air passages) of the lungs.
| Trade Name | Isoetarinum |
| Availability | Discontinued |
| Generic | Isoetharine |
| Isoetharine Other Names | Isoetarina, Isoetarinum, Isoetharine |
| Related Drugs | Trelegy Ellipta, prednisone, Breo Ellipta, Xopenex, Dulera, Atrovent, Fasenra |
| Type | |
| Formula | C13H21NO3 |
| Weight | Average: 239.3107 Monoisotopic: 239.152143543 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of asthma, wheezing, and chronic asthmatic bronchitis.
How Isoetarinum works
The pharmacologic effects of isoetharine are attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Toxicity
Signs of overdose include tachycardia, palpitations, nausea, headache, and epinephrine-like side effects.
Isoetarinum Hypertension interaction
[Moderate] Adrenergic bronchodilators can stimulate cardiovascular beta- 1 and beta- 2 receptors, resulting in adverse effects such as tachycardia, palpitation, peripheral vasodilation, blood pressure changes, and ECG changes (e.g., flattening of the T wave; prolongation of the QT interval; ST segment depression).
Direct stimulation of cardiac tissues is mediated by beta- 1 receptors and thus less likely to occur with beta-2-selective agents such as albuterol.
However, beta-2-selectivity is not absolute and can be lost with larger doses.
High dosages of these agents have been associated with precipitation or aggravation of angina, myocardial ischemia, and cardiac arrhythmias.
Therapy with adrenergic bronchodilators should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, and The recommended dosages should not be exceeded.
Isoetarinum Disease Interaction
Innovators Monograph
You find simplified version here Isoetarinum
