Isophosphoramide Mustard
Isophosphoramide Mustard Uses, Dosage, Side Effects, Food Interaction and all others data.
Isophosphoramide Mustard (ZIO-201) is a proprietary stabilized metabolite of ifosfamide. Ifosfamide has been shown to be effective in high doses in treating testicular cancer, sarcoma and lymphoma.
| Trade Name | Isophosphoramide Mustard |
| Generic | Palifosfamide |
| Palifosfamide Other Names | Ifosfamide mustard, Ifosforamide mustard, Isophosphamide mustard, Isophosphoramide mustard, Palifosfamide |
| Type | |
| Formula | C4H11Cl2N2O2P |
| Weight | Average: 221.022 Monoisotopic: 219.993519532 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
How Isophosphoramide Mustard works
After metabolic activation, palifosfamide alkylates or binds with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily due to cross-linking of strands of DNA and RNA, as well as inhibition of protein synthesis.
Innovators Monograph
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