Капреомицин-ДЕКО
Капреомицин-ДЕКО Uses, Dosage, Side Effects, Food Interaction and all others data.
Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.
Капреомицин-ДЕКО is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).
Trade Name | Капреомицин-ДЕКО |
Availability | Discontinued |
Generic | Capreomycin |
Capreomycin Other Names | Capreomicina, Capreomycin |
Related Drugs | ciprofloxacin, levofloxacin, Levaquin, rifampin |
Type | |
Formula | C50H88N28O15 |
Weight | Average: 1321.4123 Monoisotopic: 1320.698394286 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
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Uses
Капреомицин-ДЕКО is an aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
Used in the treatment of tuberculosis in combination with other drugs.
Капреомицин-ДЕКО is also used to associated treatment for these conditions: Tuberculosis (TB)
How Капреомицин-ДЕКО works
Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Капреомицин-ДЕКО also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria.
Toxicity
Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.
Food Interaction
No interactions found.Капреомицин-ДЕКО Drug Interaction
Major: RHO Immunoglobulin , RHO Immunoglobulin Moderate: ciprofloxacin, ciprofloxacinUnknown: 5-hydroxytryptophan, 5-hydroxytryptophan, vitamin a & d topical, vitamin a & d topical, acetylcysteine, acetylcysteine, aspirin, aspirin, glucose, glucose, heparin, heparin, acetaminophen, acetaminophen, cholecalciferol, cholecalciferol
Капреомицин-ДЕКО Disease Interaction
Major: hearing loss, renal dysfunctionModerate: hypokalemia, liver impairment, magnesium and calcium imbalance
Elimination Route
Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.
Elimination Route
When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours.
Innovators Monograph
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