KB001
KB001 Uses, Dosage, Side Effects, Food Interaction and all others data.
KB001 is a Humaneeredâ„¢ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients.
KaloBios is developing KB001, a PEGylated engineered human Fab' fragment for the prevention and treatment of Pseudomonas aeruginosa infections. The Fab' fragment is specific for the PcrV antigen, an essential component of the Type III secretion system, a key virulence factor with multiple roles in both infection and pathogenesis. KB001 shows potent activity in mouse models of pulmonary infection, reducing mortality and leading to effective clearance of bacteria from infected lungs. This molecule therefore represents an attractive candidate for clinical evaluation in the prevention or treatment of Pseudomonas infection in Cystic Fibrosis, pneumonia, and other indications.
Trade Name | KB001 |
Generic | KB001 |
Type | |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of infections caused by multi-drug resistant Pseudomonas aeruginosa.
How KB001 works
KB001 targets and neutralizes the PcrV protein of the Type III secretion system of the Pseudomonas bacterium, which directly inhibits its toxic effects. This mechanism of action is different from that of other antibiotics and represents a new approach in the treatment of bacterial infections.
Innovators Monograph
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