L-Aspartic Acid
L-Aspartic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
L-aspartate is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed.
| Trade Name | L-Aspartic Acid |
| Generic | Aspartic acid |
| Aspartic acid Other Names | 2-Aminosuccinic acid, ácido aspártico, Acidum asparticum, Aspartic acid, L-Asp, L-Asparaginsäure, L-Aspartate, L-Aspartic acid |
| Type | |
| Formula | C4H7NO4 |
| Weight | Average: 133.1027 Monoisotopic: 133.037507717 |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
L-Aspartic Acid is an amino acid commonly found as a component in total parenteral nutrition.
There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
L-Aspartic Acid is also used to associated treatment for these conditions: Amino acid supplementation
How L-Aspartic Acid works
There are also claims that L-aspartate has ergogenic effects, that it enhances performance in both prolonged exercise and short intensive exercise. It is hypothesized that L-aspartate, especially the potassium magnesium aspartate salt, spares stores of muscle glycogen and/or promotes a faster rate of glycogen resynthesis during exercise. It has also been hypothesized that L-aspartate can enhance short intensive exercise by serving as a substrate for energy production in the Krebs cycle and for stimulating the purine nucleotide cycle.
Toxicity
Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Food Interaction
No interactions found.Elimination Route
Absorbed from the small intestine by an active transport process
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