Lacrigel G Ophthalmic Solution 0.5%+0.9%
Lacrigel G Ophthalmic Solution 0.5%+0.9% Uses, Dosage, Side Effects, Food Interaction and all others data.
Each ml of Carboxymethylcellulose Sodium sterile eye gel drops contains: Active Substance: Carboxymethylcellulose Sodium USP 10 mg. Preservative: Purite 0.0075%Glycerin is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.
Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.
Trade Name | Lacrigel G Ophthalmic Solution 0.5%+0.9% |
Generic | Carboxymethylcellulose Sodium + Glycerin |
Weight | 0.5%+0.9% |
Type | Ophthalmic Solution |
Therapeutic Class | Drugs for Dry eyes |
Manufacturer | Opsonin Pharma Ltd. |
Available Country | Bangladesh |
Last Updated: | October 19, 2023 at 6:27 am |
Uses
This Sterile Eye Drops is indicated for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.Lacrigel G Ophthalmic Solution 0.5%+0.9% is also used to associated treatment for these conditions: Cold Sore, Constipation, Dry Mouth, Dry Skin, Dry throat, Edema of the cerebrum, Hypertension Intracranial, Occasional Constipation, Ocular Discomfort, Ocular Hypertension, Ocular Irritation, Skin Infections, Sore Throat, Mouth soreness, Ocular burning, Bowel preparation therapy, Topical Antisepsis, Skin protection
How Lacrigel G Ophthalmic Solution 0.5%+0.9% works
When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.
Dosage
Lacrigel G Ophthalmic Solution 0.5%+0.9% dosage
Instill 1 drop in the affected eyes as needed.It can be used in children.Side Effects
Vision may be temporarily blurred when this product is first used. Also, minor burning/ stinging/ irritation may temporarily occur.Toxicity
Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg
Precaution
Consult doctor if irritation, eye pain or visual changes worsen or persist beyond 72 hours.Interaction
If several medicines are to be administered to the eye, there should be an interval of at least 5 minutes between each application.Volume of Distribution
Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.
Elimination Route
Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach
Half Life
30 - 45 minutes
Elimination Route
Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.
Pregnancy & Breastfeeding use
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Carboxymethylcellulose Sodium and Glycerin should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.Use in lactation: Carboxymethylcellulose Sodium or Glycerin has not been measured in human milk. Caution should be exercised when the combination of Carboxymethylcellulose Sodium and Glycerin is administered to a nursing mother.Contraindication
It is contraindicated in patients with known hypersensitivity to any ingredient of this formulation.Special Warning
Pediatric use: This eye drop should not be used in infants and small children under 3 years.Geriatric use: No overall differences in safety or effectiveness have been observed between elderly and other adult patients.Storage Condition
Store below 30°C. Protect from light. Do not use longer than 1 month after 1st opening. Do not freeze.Innovators Monograph
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