Lacrisert

Lacrisert Uses, Dosage, Side Effects, Food Interaction and all others data.

Lacrisert is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.

Lacrisert (cellulose, 2-hydroxypropyl ether) is a derivative of cellulose with both water solubility and organic solubility. Lacrisert acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Lacrisert also acts to lubricate and protect the eye. Lacrisert usually reduces the signs and symptoms resulting from moderate to severe dry eye syndromes, such as conjunctival hyperemia, corneal and conjunctival staining with rose bengal, exudation, itching, burning, foreign body sensation, smarting, photophobia, dryness and blurred or cloudy vision. Progressive visual deterioration which occurs in some patients may be retarded, halted, or sometimes reversed.

Lacrisert
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
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Trade Name	Lacrisert
Generic	Hydroxypropyl cellulose
Hydroxypropyl cellulose Other Names	Cellulose hydroxypropyl ether, Hiprolosa, Hydroxypropyl cellulose, Hydroxypropylcellulose, Hyprolose, Hyprolosum, Modified cellulose
Type	Ophthalmic
Protein binding	None
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Lacrisert is a cellulose ether used to treat dry eyes.

Used to relieve dryness and irritation caused by reduced tear flow that occurs in certain eye diseases (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes.

Lacrisert is also used to associated treatment for these conditions: Corneal Erosions, Corneal Inflammation, Dry Eye Syndrome (DES), Keratoconjunctivitis Sicca

How Lacrisert works

Lacrisert is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Lacrisert possesses good surface activity but does not gel as it forms open helical coils. In general Lacrisert is a water-soluble thickener, emulsifier and film-former often used in tablet coating.

Toxicity

LD₅₀=10200 mg/kg (oral, rat)

Food Interaction

No interactions found.

Elimination Route

Studies conducted in rats fed 14 C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.

Elimination Route

Studies conducted in rats fed 14C-labeled hydroxypropyl cellulose demonstrated that when orally administered, hydroxypropyl cellulose is not absorbed from the gastrointestinal tract and is quantitatively excreted in the feces.