Lamoxactam

Lamoxactam Uses, Dosage, Side Effects, Food Interaction and all others data.

Lamoxactam is a broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.

Lamoxactam works by inhibiting bacterial cell wall biosynthesis.

Lamoxactam
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Lamoxactam
Generic	Latamoxef
Latamoxef Other Names	Festamoxin, Lamoxactam, Latamoxef, Latamoxefum, Moxalactam
Type
Formula	C₂₀H₂₀N₆O₉S
Weight	Average: 520.473 Monoisotopic: 520.101246958
Protein binding	40%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Lamoxactam is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Lamoxactam is primarily indicated in conditions like Bone and joint infection, GI infections, Gynecological infections, Meningitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI.

How Lamoxactam works

Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain (the penicillin-binding protein) by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.

Toxicity

Lamoxactam produces potentially life-threatening effects which include Bleeding, Hypothrombinemia, Platelet dysfunctioning. which are responsible for the discontinuation of Lamoxactam therapy. The symptomatic adverse reactions produced by Lamoxactam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin rashes, Hematuria, Hyperuricemia, Pyuria, Raised serum creatinine.