Trimethylpsoralen
Trimethylpsoralen Uses, Dosage, Side Effects, Food Interaction and all others data.
Trimethylpsoralen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. The photoactivated form produces interstrand linkages in DNA resulting in cell apoptosis. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.[3] The compound is has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Trimethylpsoralen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue.
| Trade Name | Trimethylpsoralen |
| Availability | Discontinued |
| Generic | Trioxsalen |
| Trioxsalen Other Names | Trimethylpsoralen, Trioxisaleno, Trioxsalen, Trioxysalen, Trioxysalene, Trioxysalenum, Trisoralen |
| Related Drugs | Humira, Cosentyx, methotrexate, Remicade, Stelara, cyclosporine, infliximab |
| Type | |
| Formula | C14H12O3 |
| Weight | Average: 228.2433 Monoisotopic: 228.07864425 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Trimethylpsoralen is a psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer.
Trimethylpsoralen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.
How Trimethylpsoralen works
After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
Food Interaction
- Avoid foods high in furanocoumarins. Eating these foods while you are taking trioxsalen may increase your skin's sensitivity to sunlight. Examples include limes, figs, parsley, parsnips, mustard, carrots, and celery.
Trimethylpsoralen Disease Interaction
Innovators Monograph
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