Larazotide Uses, Dosage, Side Effects and more
An octapeptide inhibitor of paracellular permeability whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease.
| Trade Name | Larazotide |
| Generic | Larazotide |
| Larazotide Other Names | Larazotide |
| Type | |
| Formula | C32H55N9O10 |
| Weight | Average: 725.845 Monoisotopic: 725.407189007 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in autoimmune diseases, diabetes mellitus type 1, and gastrointestinal diseases and disorders (miscellaneous).
How Larazotide works
AT-1001 is an orally administered octapeptide zonulin receptor antagonist that appears to exert its inhibitory effect on gliadin-induced tight junction disassembly by blocking putative zonulin receptors on the luminal surface of the small intestine.
