Laronidase (genetical Recombination)

Laronidase (genetical Recombination) Uses, Dosage, Side Effects, Food Interaction and all others data.

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase (genetical Recombination) is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.

Laronidase (genetical Recombination) is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.

Table Of contents

• Laronidase (genetical Recombination)
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Laronidase (genetical Recombination)
Availability	Prescription only
Generic	Laronidase
Laronidase Other Names	alpha-L-Idosiduronase, Human Recombinant alpha-L-iduronidase, Laronidasa, Laronidase, Laronidase (genetical recombination)
Related Drugs	Aldurazyme
Type
Formula	C3160H4848N898O881S12
Weight	69899.4 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Laronidase (genetical Recombination) is a form of recombinant human alpha-L-iduronidase used to treat Hurler and Hurler-Scheie forms of mucopolysaccharidosis, a genetic deficiency of alpha-L-iduronidase.

For the treatment of mucopolysaccharidosis

Laronidase (genetical Recombination) is also used to associated treatment for these conditions: Type 1 Mucopolysaccharidosis

How Laronidase (genetical Recombination) works

Laronidase (genetical Recombination) catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.

Food Interaction

No interactions found.

Laronidase (genetical Recombination) Disease Interaction

Major: hypersensitivity

Half Life

1.5-3.6 hrs

Innovators Monograph

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