Leucenine
Leucenine Uses, Dosage, Side Effects, Food Interaction and all others data.
Leucenine is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
Leucenine inhibits DNA synthesis at the level of elongation of nascent chains by altering deoxyribonucleotide metabolism. It arrests the cell cycle in the late G(1) phase.
| Trade Name | Leucenine |
| Generic | Mimosine |
| Mimosine Other Names | L-Mimosine, Leucaenine, Leucaenol, Leucenine, Leucenol, Mimosin |
| Type | |
| Formula | C8H10N2O4 |
| Weight | Average: 198.176 Monoisotopic: 198.064056818 |
| Protein binding | >99.5% |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How Leucenine works
Leucenine causes inhibition of DNA replication, changes in the progression of the cells in the cell cycle, and apoptosis. Leucenine appears to introduce breaks into DNA. Leucenine is an iron/zinc chelator. Iron depletion induces DNA double-strand breaks in treated cells, and activates a DNA damage response that results in focal phosphorylation of histones. This leads to inhibition of DNA replication and/or DNA elongation. Some studies indicate that mimosine prevents the initiation of DNA replication, whereas other studies indicate that mimosine disrupts elongation of the replication fork by impairing deoxyribonucleotide synthesis by inhibiting the activity of the iron-dependent enzyme ribonucleotide reductase and the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT). Inhibition of serine hydroxymethyltransferase is moderated by a zinc responsive unit located in front of the SHMT gene.
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