Leucopeptin
Leucopeptin Uses, Dosage, Side Effects, Food Interaction and all others data.
Leucopeptin, a peptide antibiotic, is in clinical development for the treatment of cystic fibrosis. Leucopeptin is a 19-amino-acid tetracyclic peptide produced by Streptoverticillium cinnamoneus and is closely related to cinnamycin (Ro09-0198). It belongs to the lantibiotics. Lantibiotics are bacteriocins that are characterized by the presence of a high proportion of unusual amino acids.
| Trade Name | Leucopeptin |
| Generic | Lancovutide |
| Lancovutide Other Names | Duramycin, Lancovutide, Leucopeptin |
| Type | |
| Formula | C89H125N23O25S3 |
| Weight | Average: 2013.3 Monoisotopic: 2011.837910139 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in cystic fibrosis and eye disorders/infections.
How Leucopeptin works
Duramycin becomes deposited in cellular membranes where it binds to phosphatidylethanolamine. It may thereby change biophysical membrane properties and perturb ion channel function. Duramycin stimulates secretion of electrically charged atoms (ions) of chloride from epithelial cells in the lungs. Increased chloride secretion is accompanied by obligatory increase in water secretion from same cells. This may prevent the thickening of lung secretions and prevent further mucus build up and its progressive contribution to lung tissue damage.
Innovators Monograph
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