Leukase N

Leukase N Uses, Dosage, Side Effects, Food Interaction and all others data.

Leukase N is an aminoglyoside antibiotic which is the major component of neomycin. Susceptible organisms include many gram-negative bacteria (but not Pseudomonas) and many strains of Staphylococcus. Used topically in the treatment of skin, eye and ear infections often in combination with steroids and other antimicrobials.

Leukase N is used for the treatment of bacterial eye infections such as conjunctivitis. Leukase N is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Leukase N works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Leukase N is useful primarily in infections involving aerobic bacteria bacteria.

Table Of contents

• Leukase N
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Leukase N
Generic	Framycetin
Framycetin Other Names	Fradiomycin B, Framicetina, Framycetin, Framycétine, Framycetinum, Neomycin B
Type
Formula	C23H46N6O13
Weight	Average: 614.6437 Monoisotopic: 614.312285588
Groups	Approved
Therapeutic Class	Dressing products for wounds/burns/ulcers, Ophthalmic antibacterial drugs
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Abrasion, Bites, Blepharitis, Conjunctivitis, Conjunctivitis, blepharitis and blepharoconjunctivitis, Dermatitis, Eye infections, Lactation, Ocular infections, Posttraumatic or pre- and postoperative otitis externa, Skin infections, Wounds

Leukase N is also used to associated treatment for these conditions: Acute Crusting Rhinitis, Conjunctivitis, Corneal Abrasions, Infection, Skin Infections, Bacterial, Stye, Ulcerative keratitis, Acute rhino-sinusitis, Bacterial blepharitis, Nasal carriage of staphylococci

How Leukase N works

Leukase N binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Dosage

Leukase N dosage

Ophthalmic-

Conjunctivitis, blepharitis and blepharoconjunctivitis: As 0.5% ointment. Apply 2-3 times daily into the affected eyes.Otic/Aural-

Posttraumatic or pre- and postoperative otitis externa: As 0.5% drops: Use as directed.Topical/Cutaneous-

Skin infections: As sulfate: Apply 1% dressing onto affected area.

Side Effects

Ototoxicity, if large areas used in high-risk groups; sensitisation, contact dermatitis, local irritation and itching.

Precaution

If large areas of skin are being treated, ototoxicity may be a hazard, particularly in children, elderly and those with renal impairment. Pregnancy.

Interaction

Co-admin of gramicidin with framycetin reduces the risk of selecting resistant bacteria.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Pregnancy category-C

Contraindication

Hypersensitivity, perforated ear drums (ear drops), fungal/viral or resistant bacterial eye infections (eye drops with steroids).

Innovators Monograph

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